Sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice

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Sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice

Sodium 4-phenylbutyrate (PBA) exhibits anti-inflammatory effects by suppressing nuclear factor-κB (NF-κB) activation. In the present study, the effects of PBA on a mouse model of dextran sulfate sodium (DSS)-induced colitis were investigated. The therapeutic efficacy of PBA (150 mg/kg body weight) in DSS-induced colitis was assessed based on the disease activity index (DAI), colon length, the p...

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ژورنال

عنوان ژورنال: Experimental and Therapeutic Medicine

سال: 2013

ISSN: 1792-0981,1792-1015

DOI: 10.3892/etm.2013.1456